February 11, 2019Open Access
View Full PaperReduced Loop Diuretic Use in Patients Taking Sacubitril/Valsartan Compared with Enalapril: The PARADIGM-HF Trial
Structured PICO
Does sacubitril/valsartan reduce the requirement for loop diuretics compared with enalapril in patients with heart failure with reduced ejection fraction?
P
Population
Patients with heart failure with reduced ejection fraction
I
Intervention
Sacubitril/valsartan
C
Comparator
Enalapril
O
Outcome
Loop diuretic dose reductions and dose increases
Sacubitril/valsartan may reduce the requirement for loop diuretics relative to enalapril in patients with HFrEF.
Abstract
Treatment with sacubitril/valsartan was associated with more loop diuretic dose reductions and fewer dose increases compared with enalapril, suggesting that treatment with sacubitril/valsartan may reduce the requirement for loop diuretics relative to enalapril in patients with heart failure with reduced ejection fraction.