Why the study?
Does sacubitril/valsartan reduce the requirement for loop diuretics compared with enalapril in patients with heart failure with reduced ejection fraction?
Does sacubitril/valsartan reduce the requirement for loop diuretics compared with enalapril in patients with heart failure with reduced ejection fraction?
Sacubitril/valsartan may reduce the requirement for loop diuretics relative to enalapril in patients with HFrEF.
Supports diuretic dose reduction with sacubitril/valsartan in HFrEF; extends ARNI benefits beyond enalapril in decongestion.
Treatment with sacubitril/valsartan was associated with more loop diuretic dose reductions and fewer dose increases compared with enalapril, suggesting that treatment with sacubitril/valsartan may reduce the requirement for loop diuretics relative to enalapril in patients with heart failure with reduced ejection fraction.
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Vardeny et al. (2019) studied this question.
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