Why the study?
Does loop diuretic use and dose affect renal function, cardiovascular mortality, and heart failure hospitalization in patients with HFrEF?
Does loop diuretic use and dose affect renal function, cardiovascular mortality, and heart failure hospitalization in patients with HFrEF?
In patients with HFrEF, higher doses of loop diuretics are associated with increased risks of cardiovascular mortality and heart failure hospitalization, alongside a slight decline in renal function.
Caution with higher loop diuretic doses in HFrEF; leaves open causality versus confounding in renal and CV outcomes.
The use of loop diuretics was associated with a slightly greater rate of decline in eGFR, which did not vary significantly by diuretic dose.Loop diuretic dose was associated with higher risks of (CV) mortality and predominantly hospitalization owing to HF, which appeared to be higher among those receiving higher daily doses.
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Damman et al. (2015) studied this question.
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