October 1, 2005European Journal of Heart Failure

A Statin in the Treatment of Heart Failure? Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA): Study Design and Baseline Characteristics

View Full Paper

Ask AI

Bookmark

Why the study?

Does rosuvastatin reduce cardiovascular mortality, non-fatal MI, or non-fatal stroke in elderly patients with chronic symptomatic systolic heart failure of ischemic etiology?

Population

Men and women, aged ≥60 years with chronic symptomatic systolic heart failure of ischemic etiology and…

Comparison

Rosuvastatin 10 mg vs Placebo

Design

RCT, randomized, double-blind

Authors

JKJohn KjekshusHeart Failure & Transplant PDPeter DunselmanAmphia Ziekenhuis MBMalin BlideskogAstraZeneca (Sweden)

Discussion

Member takes

Implication

Addresses evidence gap for statins in elderly ischemic HF; RCT will deliver first dedicated outcome data to inform use.

Structured PICO

Does rosuvastatin reduce cardiovascular mortality, non-fatal MI, or non-fatal stroke in elderly patients with chronic symptomatic systolic heart failure of ischemic etiology?

Population

Men and women, aged ≥60 years with chronic symptomatic systolic heart failure of ischemic etiology and ejection fraction ≤0.40 (NYHA class III and IV) or ≤0.35 (NYHA class II), not using or in need of cholesterol lowering drugs (n=5016).

Intervention

Rosuvastatin 10 mg

Comparator

Placebo

Outcome

Combined endpoint of cardiovascular mortality, non-fatal myocardial infarction or non-fatal stroke (time to first event)composite

The CORONA trial is designed to evaluate whether rosuvastatin improves outcomes in elderly patients with ischemic systolic heart failure.

Cite This Study

Kjekshus et al. (2005) studied this question.

synapsesocial.com/papers/6a76aa274c326aeb7c06166a https://doi.org/10.1016/j.ejheart.2005.09.005

Topics

Statin therapy Heart failure HFrEF treatment

View Full Paper

Ask AI

Bookmark

A Statin in the Treatment of Heart Failure? Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA): Study Design and Baseline Characteristics

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

A Statin in the Treatment of Heart Failure? Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA): Study Design and Baseline Characteristics

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider