Key result
Chronic diuretic use is linked to increased long-term mortality and hospitalizations in chronic heart failure.
Why the study?
The impact of chronic diuretic use on long-term mortality and hospitalizations in ambulatory chronic systolic and diastolic heart failure patients was uncertain.
Does chronic diuretic use increase long-term mortality and hospitalizations in ambulatory chronic systolic and diastolic HF patients?
Observational
Does chronic diuretic use increase long-term mortality and hospitalizations in ambulatory chronic systolic and diastolic HF patients?
Chronic diuretic use in asymptomatic or minimally symptomatic heart failure patients without fluid retention may be associated with increased mortality and hospitalizations, challenging the routine use of these agents.
May signal harm from chronic diuretics in stable HF without congestion; leaves open causal confirmation in RCTs.
Chronic diuretic use was associated with increased long-term mortality and hospitalizations in a wide spectrum of ambulatory chronic systolic and diastolic HF patients. The findings of the current study challenge the wisdom of routine chronic use of diuretics in HF patients who are asymptomatic or minimally symptomatic without fluid retention, and are on complete neurohormonal blockade. These findings, based on a non-randomized design, need to be further studied in randomized trials.
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Ahmed et al. (2006) conducted an observational in Heart failure. Chronic diuretic use was evaluated on Long-term mortality and hospitalizations. Chronic diuretic use was associated with increased long-term mortality and hospitalizations in ambulatory patients with chronic systolic and diastolic heart failure.
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