NFκB serves as a key functional link in the crosstalk between inflammation and cardiovascular diseases, representing a potential therapeutic target for the failing heart.
NFκB is a key functional link between inflammation and cardiovascular diseases, representing a potential therapeutic target for heart failure.
Inflammation is a key mechanism of cardiovascular diseases. It is an essential component of atherosclerosis and a significant risk factor for the development of cardiovascular events. In the crosstalk between inflammation and cardiovascular diseases, the transcription factor NFκB seems to be a key player since it is involved in the development and progression of both inflammation and cardiac and vascular damage. In this review, we deal with the recent findings of the role of inflammation in cardiac diseases, focusing, in particular, on NFκB as a functional link. We describe strategies for the therapeutic targeting of NFκB as a potential strategy for the failing heart.
Fiordelisi et al. (Sat,) conducted a review in Cardiovascular diseases and inflammation. Therapeutic targeting of NFκB was evaluated. NFκB serves as a key functional link in the crosstalk between inflammation and cardiovascular diseases, representing a potential therapeutic target for the failing heart.