Are low-grade elevations in cTnI and cTnT associated with distinct genetic causes and clinical outcomes in the general population?
cTnI and cTnT have distinct genetic causes and prognostic implications in the general population, with cTnI more strongly linked to CVD outcomes and cTnT to non-CVD death.
The upstream genetic causes of low-grade elevations in cTnI and cTnT appear distinct, and their associations with outcomes also differ. Elevations in cTnI are more strongly associated with some CVD outcomes, whereas cTnT is more strongly associated with the risk of non-CVD death. These findings help inform the selection of an optimal troponin assay for future clinical care and research in this setting.
Welsh et al. (Wed,) studied this question.