Cardiac Troponin T and Troponin I in the General Population

Figures

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  Figure 1.. Association of cTnI and cTnT unadjusted and adjusted (as per Table 2) with the composite CVD event. The referent (HR=1) is undetectable levels of cTnI and cTnT, respectively. Both splines on log scale. cTnI indicates high-sensitivity cardiac troponin I; cTnT, high-sensitivity cardiac troponin T; CVD, cardiovascular disease; and HR, hazard ratio.

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  Figure 2.. Rates of CVD per 1000 person-years (n=1177 events) by low/intermediate/high groupings of both cTnI and cTnT. For cTnI: low ≤1.8ng/L (n=9426), intermediate 1.9 to 3.0 ng/L (n=5052), and high ≥3.1 ng/L (n=5023). For cTnT: low ≤3.0 ng/L (n=9106), intermediate 3.0 to 5.7 ng/L (n=5200), and high ≥5.8 ng/L (n=5195). cTnI indicates high-sensitivity cardiac troponin I; cTnT, high-sensitivity cardiac troponin T; and CVD, cardiovascular disease.

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  Figure 3.. Manhattan plots for single-nucleotide polymorphisms associated with cTnI and cTnT after adjustment for age and sex (n=19 130). A, cTnI. B, cTnT. The horizontal black dotted line indicates genome-wide significance at P<5×10–8, and the horizontal gray dotted line suggests significance at P<1×10–5.