Comparison between High-Sensitivity Cardiac Troponin T and Cardiac Troponin I in a Large General Population Cohort
Key result
hs-cTnT and hs-cTnI are widely detectable in the general population but only weakly correlated.
- n=19,501
Why the study?
How do high-sensitivity cardiac troponin T and I compare in their distribution and association with cardiovascular risk factors in a general population?
Population
19,501 individuals in the Generation Scotland Scottish Family Health Study
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Weak hs-cTnT/hs-cTnI correlation suggests assay-specific thresholds; leaves open comparative prognostic value in primary prevention.
Study Design
Type
Cohort (n=19,501)
Structured PICO
How do high-sensitivity cardiac troponin T and I compare in their distribution and association with cardiovascular risk factors in a general population?
P
Population
19,501 individuals in the Generation Scotland Scottish Family Health Study
I
Intervention
Measurement of high-sensitivity cardiac troponin T (cTnT) and cardiac troponin I (cTnI)
O
Outcome
Distribution and association between cTnT, cTnI, and cardiovascular risk factorssurrogate
Main Result
Absolute Event Rate: 53.3% vs 74.8%
In the general population, cTnT and cTnI are weakly correlated and differentially associated with cardiovascular risk factors, and the currently used 99th centiles may not be appropriate for individuals over 60 years of age.
Cite This Study
Welsh et al. (2018) conducted a cohort in General population (n=19,501). High-sensitivity cardiac troponin T (cTnT) vs. High-sensitivity cardiac troponin I (cTnI) was evaluated on Detectable concentrations and correlation between cTnT and cTnI. High-sensitivity cTnT and cTnI concentrations were detectable in 53.3% and 74.8% of the general population, respectively, and were only weakly correlated after adjusting for age and sex (R2 = 9.5%).