April 29, 2019Open Access
Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis
Structured PICO
P
Population
Patients with aortic stenosis (AS)
O
Outcome
Valve calcification and disease progressionsurrogate
Lp(a) and OxPL are implicated in driving valve calcification and progression of aortic stenosis, providing a mechanistic rationale for future clinical trials targeting these pathways.
Abstract
In patients with AS, Lp(a) and OxPL drive valve calcification and disease progression. These findings suggest lowering Lp(a) or inactivating OxPL may slow AS progression and provide a rationale for clinical trials to test this hypothesis.
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Authors
K
Kang H. Zheng
Fudan University
Sotirios Tsimikas
Vascular Medicine
T
Tania Pawade
Cardiac Imaging
Journals
Journal of the American College of Cardiology
Actions
Institutions
Harvard University
University of California, San Diego
Brigham and Women's Hospital
References and Citations
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