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in myeloid cells or depleting GP130 in TNBC cells attenuates obesity-augmented TNBC stemness. Moreover, weight loss reverses the effects of obesity on MMe macrophage inflammation and TNBC tumor formation. Our studies implicate MMe macrophage accumulation in mammary adipose tissue as a mechanism for promoting TNBC stemness and tumorigenesis during obesity.
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Payal Tiwari
Broad Institute
Ariane Blank
University of Chicago
Chang Cui
Beijing Institute of Technology
The Journal of Experimental Medicine
University of Chicago
Northwestern University
King's College London
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Tiwari et al. (Fri,) studied this question.
synapsesocial.com/papers/6a01d5573718553b53cae6be — DOI: https://doi.org/10.1084/jem.20181616