Does pulsed field ablation allow safe and durable pulmonary vein isolation in patients with atrial fibrillation?
First-in-human trials demonstrate that pulsed field ablation is a feasible, safe, and ultra-rapid method for pulmonary vein isolation in atrial fibrillation.
In first-in-human trials, PFA preferentially affected myocardial tissue, allowing facile ultra-rapid PV isolation with excellent durability and chronic safety. (IMPULSE: A Safety and Feasibility Study of the IOWA Approach Endocardial Ablation System to Treat Atrial Fibrillation; NCT03700385; and PEFCAT: A Safety and Feasibility Study of the FARAPULSE Endocardial Ablation System to Treat Paroxysmal Atrial Fibrillation; NCT03714178).
Reddy et al. (Fri,) studied this question.