Why the study?
Does pulsed field ablation allow safe and durable pulmonary vein isolation in patients with atrial fibrillation?
Does pulsed field ablation allow safe and durable pulmonary vein isolation in patients with atrial fibrillation?
First-in-human trials demonstrate that pulsed field ablation is a feasible, safe, and ultra-rapid method for pulmonary vein isolation in atrial fibrillation.
PFA shows early promise for AF ablation; hypothesis-generating and requires randomized trials before practice change.
In first-in-human trials, PFA preferentially affected myocardial tissue, allowing facile ultra-rapid PV isolation with excellent durability and chronic safety. (IMPULSE: A Safety and Feasibility Study of the IOWA Approach Endocardial Ablation System to Treat Atrial Fibrillation; NCT03700385; and PEFCAT: A Safety and Feasibility Study of the FARAPULSE Endocardial Ablation System to Treat Paroxysmal Atrial Fibrillation; NCT03714178).
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Reddy et al. (2019) studied this question.
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