Ambulatory cuff-based oscillometric pulse wave velocity is nearly completely explained by age and systolic blood pressure, which together account for 99.1% of its total variance.
Observational (n=234)
Does ambulatory brachial cuff-based oscillometric PWV (oPWV) correlate with carotid-femoral PWV independently of age and systolic blood pressure?
Cuff-based oscillometric pulse wave velocity derived from the Mobil-O-Graph is almost entirely mathematically determined by age and systolic blood pressure, limiting its utility as an independent measure of arterial stiffness.
Effect estimate: 99.1% of variance
Pulse wave velocity (PWV), a measure of arterial stiffness, is an independent risk factor for cardiovascular morbidity and mortality. We investigated the relationship of ambulatory brachial cuff-based oscillometric PWV (oPWV) to 2 known correlates: age and brachial systolic blood pressure (SBP). In 234 participants in the Masked Hypertension Study, we analyzed 7284 validated hourly ambulatory SBP and oPWV readings using the Mobil-O-Graph monitor, which uses a proprietary pulse wave analysis algorithm to determine oPWV. Carotid-femoral PWV (cfPWV) was also measured. Mixed linear models were developed to estimate oPWV from age and ambulatory SBP. Participants were 34% male, with mean (SD) age 52.8 (9.9) years, SBP 123.8 (18.4) mm Hg, and oPWV 7.6 (1.3) m/s and cfPWV of 7.7 (1.7) m/s. The relationship of oPWV to age and SBP is given below: Formula: see text Age uniquely accounted for an estimated 75% of the total variation of oPWV, whereas SBP uniquely accounted for 20%; these findings were confirmed in an external validation dataset. Together, age and SBP accounted for 99.1% of the total variance of oPWV but (only) 40.2% of the variance of cfPWV. The correlation between oPWV and cfPWV was 0.58 but was only 0.11 after controlling for age and SBP. We conclude that the Mobil-O-Graph's oPWV is nearly completely explained by age and SBP and its relationship to cfPWV is because of their shared associations with age and SBP. Other hemodynamic variables derived from oscillometric pulse wave analysis may be useful and deserve additional scrutiny.
Schwartz et al. (Tue,) conducted a observational in Masked Hypertension (n=234). Age and systolic blood pressure was evaluated on Variance of oscillometric pulse wave velocity (oPWV) explained by age and SBP (99.1% of variance). Ambulatory cuff-based oscillometric pulse wave velocity is nearly completely explained by age and systolic blood pressure, which together account for 99.1% of its total variance.