August 12, 2019Open Access

A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients

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Abstract

Opportunities to improve upon identification of patients at risk for hereditary cancer predisposition include revising BRCA1/2 and Lynch syndrome testing criteria to include additional clinically actionable genes with overlapping phenotypes and relaxing testing criteria for associated cancers.

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LaDuca et al. (Mon,) studied this question.

synapsesocial.com/papers/69dabfaa37b5141e3ba3c8b5 https://doi.org/https://doi.org/10.1038/s41436-019-0633-8

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