Compared to systolic-diastolic hypertension, isolated systolic hypertension had a 4.1-fold, 3.1-fold, and 1.6-fold greater risk of white-coat hypertension at younger, intermediate, and older ages.
Cross-Sectional (n=17,945)
Yes
Does isolated systolic or diastolic hypertension increase the risk of white-coat hypertension phenotypes compared to systolic-diastolic hypertension across different age groups?
Isolated systolic and diastolic hypertension are associated with a significantly higher prevalence of white-coat hypertension phenotypes compared to systolic-diastolic hypertension across all age groups.
Odds Ratio: 4.1
p-value: p=<0.05
OBJECTIVE: The current study investigated the prevalence of white-coat hypertension (WCH) and white-coat uncontrolled hypertension (WUCH) throughout the age spectrum among individuals with office isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH) and systolic-diastolic hypertension (SDH) who were untreated or treated with antihypertensive medications, respectively. METHODS: We cross-sectionally evaluated 8809 untreated (42% males, 52.1 ± 16.2 years) and 9136 treated (39% males, 59.7 ± 14.5 years) individuals from two independent Brazilian populations who underwent home blood pressure monitoring. Participants were also categorized as younger (<40 years), intermediate (≥40 and <60 years) and older (≥60 years) age. RESULTS: Unadjusted and adjusted analyses showed that the frequency of WCH and WUCH was significantly greater (P < 0.05) in ISH and IDH than SDH at all age groups. Logistic regression analysis adjusted for sex, BMI and studied population showed that, compared with SDH, ISH had in average 4.1, 3.1 and 1.6-fold greater risk of WCH and 3.3, 3.6 and 2.0-fold greater risk of WUCH at younger, intermediate and older ages, whereas IDH had in average 2.3, 2.6 and 2.0-fold greater risk of WCH and 3.8, 3.2 and 3.8-fold greater risk of WUCH at younger, intermediate and older ages, respectively. CONCLUSION: ISH and IDH were associated with higher prevalence of WCH and WUCH than SDH across all age spectrum. In addition, treated and untreated ISH individuals with age less than 60 years and treated IDH individuals of all ages had the highest risk of having WCH phenotypes.
Feitosa et al. (Mon,) conducted a cross-sectional in Hypertension (n=17,945). Isolated systolic hypertension (ISH) and isolated diastolic hypertension (IDH) vs. Systolic-diastolic hypertension (SDH) was evaluated on White-coat hypertension (WCH) and white-coat uncontrolled hypertension (WUCH) (OR 4.1, p=<0.05). Compared to systolic-diastolic hypertension, isolated systolic hypertension had a 4.1-fold, 3.1-fold, and 1.6-fold greater risk of white-coat hypertension at younger, intermediate, and older ages.