Does serum myoglobin accurately detect acute myocarditis and correlate with LGE on CMR in patients with suspected acute myocarditis?
Serum myoglobin is an accurate, early biomarker for detecting acute myocarditis and correlates strongly with the extent of late gadolinium enhancement on CMR, outperforming high-sensitivity troponin T.
Abstract There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (r s = 0.73 95% CI 0.51; 0.87, p < 0.001), while correlation was weak between LGE and TnT-hs (r s = 0.37 95% CI 0.09; 0.61, p = 0.01). Receiver operating curve (ROC) analysis determined myoglobin ≥ 87 μg/L as cutoff to identify myocarditis (92% sensitivity, 80% specificity). The data were reproduced in an established model of coxsackievirus B3 myocarditis in mice ( n = 26). These data suggest that myoglobin is an accurate marker of acute myocarditis.
Kottwitz et al. (Fri,) studied this question.
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