Myoglobin for Detection of High-Risk Patients with Acute Myocarditis

Figures

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  Fig. 1. Correlation of circulating cardiac and inflammatory markers with late gadolinium enhancement (LGE) in acute myocarditis: LGE as % of left ventricular myocardial volume is illustrated on the x-axis. Levels of a high-sensitivity troponin T (TnT-hs), b creatine kinase (CK), c myoglobin (Mb), and d C-reactive protein (CRP) are demonstrated on the y-axis. rs = Spearman rank correlation coefficient

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  Fig. 2. Receiver operating curve analysis to obtain optimal cutoffs for myoglobin (panel a) and high sensitivity troponin T (panel b) to identify patients with acute myocarditis and LGE on CMR

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  Fig. 3. Time course of cardiac and inflammatory markers during acute myocarditis: Time points of blood collection are illustrated on the x-axis. Mean levels of the examined blood parameters are demonstrated on the y-axis. Standard deviation is indicated in panel a. Panel b shows mean levels of myoglobin at given time points. The dotted red line indicates the upper reference value of myoglobin. CK, creatine kinase; CRP, C-reactive protein; Mb, myoglobin; TnT-hs, high sensitivity troponin T

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  Fig. 4. Myoglobin and high sensitivity troponin T (TnT-hs) blood levels in mice infected with heart-passaged CVB3 vs. saline controls. The panel on the left depicts myoglobin blood levels of controls (bar with diagonal stripes, n = 10 mice) and of mice with myocarditis during acute myocarditis at day 10 post infection (bar in solid black, n = 16 mice). Myoglobin was significantly elevated in myocarditis (p = 0.02). The panel on the right depicts blood levels of TnT-hs of controls (bar with diagonal stripes) and of mice with myocarditis (bar in solid black). There was no significant difference in TnT-hs blood levels between mice with myocarditis vs. controls. Data show the mean ± SEM. Significance determined using Student’s t test

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  Fig. 5. Correlation between high sensitivity troponin T and myoglobin in sera from mice with CVB3 myocarditis at day 10 post infection (rp = 0.48 R2 = 0.41, p = 0.007). rp = Pearson’s correlation coefficient. n = 26 mice

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  Fig. 6. Receiver operating curve analysis to obtain optimal cutoffs for myoglobin (panel a) and high sensitivity troponin T (panel b) to assess diagnostic accuracy of these markers in mice with acute CVB3 myocarditis