A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8 + T cells in mice

OBJECTIVE: engages the immune response in CAC. DESIGN: or Amuc₁100 on the immune response in acute colitis and CAC were investigated. RESULTS: and Amuc₁100 blunted tumourigenesis by expanding CTLs in the colon and MLN. Remarkably, they activated CTLs in the MLN, as indicated by TNF-α induction and PD-1downregulation. Amuc₁100 could stimulate and activate CTLs from splenocytes in CT26 cell conditioned medium. CONCLUSIONS: or Amuc₁100 can blunt colitis and CAC through the modulation of CTLs.