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N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A is installed by m6A methyltransferases (METTL3/14, WTAP, RBM15/15B, VIRMA and ZC3H13, termed "writers"), removed by demethylases (FTO, ALKBH5, and ALKBH3, termed "erasers"), and recognized by m6A-binding proteins (YTHDC1/2, YTHDF1/2/3, IGF2BP1/2/3, HNRNP, and eIF3, termed "readers"). Accumulating evidence suggests that m6A RNA methylation greatly impacts RNA metabolism and is involved in the pathogenesis of many kinds of diseases, including cancers. In this review, we focus on the physiological functions of m6A modification and its related regulators, as well as on the potential biological roles of these elements in human tumors.
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Tianyi Wang
Shan Kong
Mei Tao
Molecular Cancer
SHILAP Revista de lepidopterología
Nantong University
Affiliated Hospital of Nantong University
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Wang et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69d8ccfcb0225cae72bedccc — DOI: https://doi.org/10.1186/s12943-020-01204-7
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