Clerodendrum volubile ethanol leaf extract (50–400 mg/kg/day) significantly attenuated increases in serum LDH and troponin I levels and improved cardiac histological lesions in DOX-treated rats.
Does Clerodendrum volubile Ethanol Leaf Extract (CVE) reduce doxorubicin-induced cardiotoxicity in Wistar rats?
Clerodendrum volubile ethanol leaf extract demonstrates cardioprotective effects against doxorubicin-induced cardiotoxicity in a rat model, likely via antioxidant mechanisms.
Doxorubicin is widely applied in hematological and solid tumor treatment but limited by its off-target cardiotoxicity. Thus, cardioprotective potential and mechanism(s) of CVE in DOX-induced cardiotoxicity were investigated using cardiac and oxidative stress markers and histopathological endpoints. 50–400 mg/kg/day CVE in 5% DMSO in distilled water were investigated in Wistar rats intraperitoneally injected with 2.5 mg/kg DOX on alternate days for 14 days, using serum troponin I and LDH, complete lipid profile, cardiac tissue oxidative stress marker assays, and histopathological examination of DOX-treated cardiac tissue. Preliminary qualitative and quantitative assays of CVE ’s secondary metabolites were also conducted. Phytochemical analyses revealed the presence of flavonoids (34.79 ± 0.37 mg/100 mg dry extract), alkaloids (36.73 ± 0.27 mg/100 mg dry extract), reducing sugars (07.78 ± 0.09 mg/100 mg dry extract), and cardiac glycosides (24.55 ± 0.12 mg/100 mg dry extract). 50–400 mg/kg/day CVE significantly attenuated increases in the serum LDH and troponin I levels. Similarly, the CVE dose unrelatedly decreased serum TG and VLDL-c levels without significant alterations in the serum TC, HDL-c, and LDL-c levels. Also, CVE profoundly attenuated alterations in the cardiac tissue oxidative stress markers’ activities while improving DOX-associated cardiac histological lesions that were possibly mediated via free radical scavenging and/or antioxidant mechanisms. Overall, CVE may play a significant therapeutic role in the management of DOX-induced cardiotoxicity in humans.
Olorundare et al. (Sat,) conducted a other in Doxorubicin-induced cardiotoxicity. Clerodendrum volubile Ethanol Leaf Extract (CVE) vs. Doxorubicin alone was evaluated on Cardiac and oxidative stress markers and histopathological endpoints (serum troponin I, LDH, lipid profile). Clerodendrum volubile ethanol leaf extract (50–400 mg/kg/day) significantly attenuated increases in serum LDH and troponin I levels and improved cardiac histological lesions in DOX-treated rats.
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