Key result
Clerodendrum volubile extract attenuates cardiac injury markers and improves histology in DOX-treated rats.
Why the study?
Doxorubicin is widely used for hematological and solid tumors but is limited by cardiotoxicity, prompting investigation into the cardioprotective potential of Clerodendrum volubile ethanol leaf extract.
Does Clerodendrum volubile Ethanol Leaf Extract (CVE) reduce doxorubicin-induced cardiotoxicity in Wistar rats?
Population
Wistar rats intraperitoneally injected with 2.5 mg/kg DOX on alternate days
Comparison
50–400 mg/kg/day CVE vs controls
Design
Preclinical animal study
Follow-up
14 days
Authors
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Hypothesis-generating for CVE in rat cardiotoxicity; leaves open human translation and should not change practice.
Does Clerodendrum volubile Ethanol Leaf Extract (CVE) reduce doxorubicin-induced cardiotoxicity in Wistar rats?
Clerodendrum volubile ethanol leaf extract demonstrates cardioprotective effects against doxorubicin-induced cardiotoxicity in a rat model, likely via antioxidant mechanisms.
Olorundare et al. (2020) studied Doxorubicin-induced cardiotoxicity. Clerodendrum volubile Ethanol Leaf Extract (CVE) vs. Doxorubicin alone was evaluated on Cardiac and oxidative stress markers and histopathological endpoints (serum troponin I, LDH, lipid profile). Clerodendrum volubile ethanol leaf extract (50–400 mg/kg/day) significantly attenuated increases in serum LDH and troponin I levels and improved cardiac histological lesions in DOX-treated rats.
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