What does this research mean for the field?

Clerodendrum volubile ethanol leaf extract ameliorates doxorubicin-induced hepatorenal toxicity in rats by suppressing oxidative stress and reducing serum markers of liver and kidney injury. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 23, 2021Pharmacology and Toxicology of Natural Medicines (ISSN 2756-6838)Open Access

Ameliorative Potential of Clerodendrum volubile Ethanol Leaf Extract on Doxorubicin-Induced Hepatorenal Toxicities in Rats

Q: What is the clinical evidence from this study?

Study design: Other. Population: Doxorubicin-induced hepatorenal toxicities. Intervention: Clerodendrum volubile ethanol leaf extract (CVE) vs. DOX-treated rats. Primary outcome: Hepatorenal toxicity (serum ALT, AST, ALP, Cr, BUN, CAT, SOD, GPx, MDA).

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Key result

Clerodendrum volubile extract mitigates doxorubicin-induced liver and kidney injury in rats.

Why the study?

Hepatorenal toxicity is a side effect of doxorubicin used in cancer treatment, and the potential protective effect of Clerodendrum volubile ethanol leaf extract was investigated.

Does Clerodendrum volubile ethanol leaf extract prevent doxorubicin-induced hepatorenal toxicities in male Wistar rats?

Population

Male Wistar rats

Comparison

Pretreatment with Clerodendrum volubile ethanol leaf extract vs doxorubicin-treated rats without extract pretreatment

Design

Preclinical experimental study

Follow-up

14 days

Authors

AAAdejuwon Adewale AdeneyeLagos State University OOOlufunke E. OlorundareUniversity of Ilorin AAAkinyele Olubiyi AkinsolaRedeemer's University

Discussion

Member takes

Implication

May protect against doxorubicin hepatorenal injury in rats; hypothesis-generating and should not change clinical practice.

Structured PICO

Does Clerodendrum volubile ethanol leaf extract prevent doxorubicin-induced hepatorenal toxicities in male Wistar rats?

Population

Male Wistar rats treated with doxorubicin to induce hepatorenal toxicities.

Intervention

Pretreatment with Clerodendrum volubile ethanol leaf extract (50 - 400 mg/kg/day, p.o) followed by intraperitoneal injection of 2.5 mg/kg of doxorubicin on alternate days for 14 days

Comparator

Doxorubicin-treated rats without extract pretreatment

Outcome

Hepatorenal toxicity assessed by renal function parameters (serum electrolytes, blood urea, creatinine) and hepatic function endpoints (AST, ALT, ALP, total protein, albumin, total bilirubin)surrogate

Clerodendrum volubile ethanol leaf extract demonstrates protective effects against doxorubicin-induced hepatorenal toxicity in a rat model, likely mediated through suppression of oxidative stress.

Cite This Study

Adeneye et al. (2021) studied Doxorubicin-induced hepatorenal toxicities. Clerodendrum volubile ethanol leaf extract (CVE) vs. DOX-treated rats was evaluated on Hepatorenal toxicity (serum ALT, AST, ALP, Cr, BUN, CAT, SOD, GPx, MDA). Oral pretreatment with Clerodendrum volubile ethanol leaf extract (50-400 mg/kg/day) ameliorated doxorubicin-induced liver and kidney injury in rats by lowering serum ALT, AST, ALP, Cr, and BUN levels.

synapsesocial.com/papers/6aad15bd716fc9c42ca87629 https://doi.org/10.52406/ptnm.v1i1.8

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Ameliorative Potential of Clerodendrum volubile Ethanol Leaf Extract on Doxorubicin-Induced Hepatorenal Toxicities in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ameliorative Potential of Clerodendrum volubile Ethanol Leaf Extract on Doxorubicin-Induced Hepatorenal Toxicities in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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