Key result
Clerodendrum volubile ethanol leaf extract significantly induced concentration-dependent vasorelaxation in phenylephrine-precontracted endothelium-intact aortic rings of normal and doxorubicin-treated rats.
Why the study?
Doxorubicin commonly induces cardiotoxicity and vascular dysfunction as off-target side effects, prompting evaluation of the vasorelaxant activity and mechanisms of Clerodendrum volubile ethanol leaf extract.
Population
Normal and DOX-pretreated endothelium intact rat aortic rings
Comparison
CVE vs receptor blockers in phenylephrine- and KCl-precontracted rings
Design
In vitro experimental organ bath study
Authors
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Should not yet change doxorubicin management in patients; hypothesis-generating for plant-derived vasorelaxants in vascular models.
p-value: p=<0.05
Clerodendrum volubile ethanol leaf extract induces vasorelaxation in doxorubicin-treated rat aortic rings via cholinergic and prostacyclin-mediated mechanisms, suggesting potential protective effects against doxorubicin-induced vascular dysfunction.
Akinsola et al. (2022) studied Doxorubicin-induced vascular dysfunction (n=10). Clerodendrum volubile ethanol leaf extract vs. Baseline pre-contracted state was evaluated on Vasorelaxation in phenylephrine-precontracted endothelium-intact aortic rings (p=<0.05). Clerodendrum volubile ethanol leaf extract significantly induced concentration-dependent vasorelaxation in phenylephrine-precontracted endothelium-intact aortic rings of normal and doxorubicin-treated rats.
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