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February 14, 2020Journal of Herbmed PharmacologyOpen Access

Alleviation of doxorubicin-induced nephrotoxicity byClerodendrum volubileleaf extract in Wistar rats: A preliminary study

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Key result

Pretreatment with methanolic extract of Clerodendrum volubile significantly improved kidney function markers and restored antioxidant status in doxorubicin-intoxicated rats.

Why the study?

Doxorubicin induces toxic side effects including renal toxicity, motivating this preliminary evaluation of methanolic leaf extract of Clerodendrum volubile against DOX-induced nephrotoxicity in rats.

Does Clerodendrum volubile leaf extract prevent doxorubicin-induced nephrotoxicity in Wistar rats?

Population

Thirty male rats

Comparison

MECV (125, 250, 500 mg/kg/d) plus DOX vs DOX alone vs 0.9% NaCl control

Design

Preliminary animal study

Authors

OMOlorunfemi R. Molehin

Discussion

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Member takes

Overview

Should not inform practice; leaves open whether MECV prevents doxorubicin nephrotoxicity in humans.

Structured PICO

Does Clerodendrum volubile leaf extract prevent doxorubicin-induced nephrotoxicity in Wistar rats?

P
Population
30 healthy adult male Wistar rats were used to investigate the protective effects of Clerodendrum volubile leaf extract against doxorubicin-induced nephrotoxicity.
I
Intervention
Methanolic leaf extract of Clerodendrum volubile (MECV) at doses of 125, 250, and 500 mg/kg/d for 12 consecutive days (8 days before and 4 days after doxorubicin administration)
C
Comparator
Doxorubicin alone (25 mg/kg i.p. single dose) and 0.9% NaCl vehicle control
O
Outcome
Serum creatinine, urea levels, and renal antioxidant parameters (glutathione peroxidase, superoxide dismutase, catalase, reduced glutathione, malondialdehyde)surrogate

Main Result

p-value: p=<0.05

Clerodendrum volubile leaf extract demonstrates protective antioxidant effects against doxorubicin-induced nephrotoxicity in a rat model.

Limitations

  • Preliminary study
  • Animal model results may not directly translate to humans
  • Exact mechanism of action behind DOX-induced nephrotoxicity remains not fully elucidated

Cite This Study

Olorunfemi R. Molehin (2020) studied Doxorubicin-induced nephrotoxicity (n=30). Methanolic extract of Clerodendrum volubile (MECV) vs. Doxorubicin only and 0.9% NaCl vehicle was evaluated on Kidney function markers (serum creatinine and urea) and oxidative stress biomarkers (p=<0.05). Pretreatment with methanolic extract of Clerodendrum volubile significantly improved kidney function markers and restored antioxidant status in doxorubicin-intoxicated rats.

synapsesocial.com/papers/6a62df2daca57fe965286bcbhttps://doi.org/10.34172/jhp.2020.18
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Also Consider

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  1. 1Ameliorative Potential of Clerodendrum volubile Ethanol Leaf Extract on Doxorubicin-Induced Hepatorenal Toxicities in Rats2021 · 5 citations
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