Key result
Vitamin E administration significantly improved serum urea, creatinine, and OHdG, and lowered caspase 3 expression in rats with Doxorubicin-induced nephrotoxicity.
Why the study?
Does Vitamin E reduce Doxorubicin-induced nephrotoxicity in albino rats?
Population
40 albino rats
Comparison
Vitamin E 250mg/kg/day daily via intramuscular… vs Doxorubicin alone, Vitamin E alone, and…
Design
Preclinical
Authors
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Does not support clinical use in doxorubicin therapy; hypothesis-generating for renoprotection trials.
Does Vitamin E reduce Doxorubicin-induced nephrotoxicity in albino rats?
Vitamin E may protect against doxorubicin-induced nephrotoxicity through antioxidant and anti-apoptotic mechanisms in a rat model.
Shoukry et al. (2018) studied Doxorubicin-induced nephrotoxicity (n=40). Vitamin E vs. Doxorubicin alone was evaluated on Serum Urea, Creatinin, OHdG, and renal tissue caspase 3 levels. Vitamin E administration significantly improved serum urea, creatinine, and OHdG, and lowered caspase 3 expression in rats with Doxorubicin-induced nephrotoxicity.
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