Key result
Vitamin E and caffeic acid reverse doxorubicin-induced hepatocellular damage in rats while N-acetylcysteine fails.
Why the study?
Do N-acetylcysteine, caffeic acid, or vitamin E protect against doxorubicin-induced hepatotoxicity in rats?
Population
32 male Wistar albino rats, weighing 250-350 g
Comparison
Caffeic acid, vitamin E, or N-acetylcysteine… vs Saline injection and doxorubicin alone without…
Design
Preclinical, Randomly divided into five groups
Follow-up
10 days
Authors
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Vitamin E and CAPE attenuated doxorubicin hepatotoxicity in rats; leaves open clinical translation and warrants human trials.
RCT (n=32)
randomly divided
Do N-acetylcysteine, caffeic acid, or vitamin E protect against doxorubicin-induced hepatotoxicity in rats?
Vitamin E and caffeic acid, but not N-acetylcysteine, effectively protect against doxorubicin-induced hepatotoxicity in a rat model.
Gökçimen et al. (2007) conducted an RCT in doxorubicin-induced hepatotoxicity (n=32). N-acetylcysteine, caffeic acid, and vitamin E vs. Doxorubicin alone and saline control was evaluated on Histopathological changes including mononuclear cell infiltration and diameters of hepatic sinusoid, terminal hepatic venule, and portal area. Vitamin E and caffeic acid, but not N-acetylcysteine, efficiently reversed doxorubicin-induced hepatocellular damage in rats.
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