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July 1, 2022Zagazig Journal of Forensic MedicineOpen Access

The Role of N-Acetyl Cysteine in Ameliorating Doxorubicin Induced Cardiotoxicity in Rats

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Why the study?

Doxorubicin is an effective chemotherapeutic drug but causes toxic side effects including cardiotoxicity, prompting investigation into the ameliorative effect of n-acetylcysteine.

Does N-acetylcysteine prevent doxorubicin-induced cardiotoxicity in albino rats?

Population

Sixty albino rats

Comparison

NAC regimens plus DOX vs DOX alone, NAC alone, and control

Design

Preclinical animal study across six groups

Authors

EMEmadeldin MahmoudAswan UniversityRHranda Hussien hussienAssiut UniversitySGSafaa GeorgeAssiut University

Discussion

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Overview

N-acetylcysteine shows cardioprotective signals in doxorubicin-treated rats; leaves open translation to human prevention strategies.

Structured PICO

Does N-acetylcysteine prevent doxorubicin-induced cardiotoxicity in albino rats?

P
Population
60 albino rats
I
Intervention
N-acetylcysteine (400 or 800 mg/kg p.o. every other day) administered before and/or concurrently with doxorubicin (5 mg/kg i.p. on days 1, 7, 14, and 21)
C
Comparator
Doxorubicin alone (5 mg/kg i.p. on days 1, 7, 14, and 21), N-acetylcysteine alone, and untreated control
O
Outcome
Cardiac injury markers (LDH, CK-MB, CTn-I), oxidative stress markers (MDA, GSH, GSH-Px), and histopathological abnormalitiessurrogate

N-acetylcysteine demonstrates cardioprotective effects against doxorubicin-induced cardiotoxicity in rats by inhibiting inflammation and oxidative stress.

Cite This Study

Mahmoud et al. (2022) studied this question.

synapsesocial.com/papers/6a7e280474ee1427e1960458https://doi.org/10.21608/zjfm.2021.71789.1075
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric oxide and oxidative stress in brain and heart of normal rats treated with doxorubicin: Role of aminoguanidine2004 · 47 citations
  2. 2Cardioprotective effect of grape-seed proanthocyanidins on doxorubicin-induced cardiac toxicity in rats2012 · 41 citations
  3. 3Thymol and Carvacrol Prevent Doxorubicin‐Induced Cardiotoxicity by Abrogation of Oxidative Stress, Inflammation, and Apoptosis in Rats2015 · 102 citations
  4. 4Ameliorative effect of naringin against doxorubicin-induced acute cardiac toxicity in rats2015 · 97 citations
  5. 5Naringenin Regulates Doxorubicin-Induced Liver Dysfunction: Impact on Oxidative Stress and Inflammation2020 · 116 citations