Key result
N-acetylcysteine demonstrated a neuroprotective effect against doxorubicin-induced brain damage in rats by inhibiting inflammation and oxidative stress.
Why the study?
Doxorubicin causes toxic effects, including cognitive impairment, leading investigators to evaluate whether n-acetylcysteine provides prophylactic and ameliorative protection against doxorubicin-induced neurotoxicity.
Does N-acetylcysteine prevent or ameliorate doxorubicin-induced neurotoxicity in Wistar rats?
Does N-acetylcysteine prevent or ameliorate doxorubicin-induced neurotoxicity in Wistar rats?
N-acetylcysteine demonstrates a neuroprotective effect against doxorubicin-induced brain damage in rats by inhibiting inflammation and oxidative stress, particularly when administered prophylactically.
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NAC may protect against DOX neurotoxicity in rats; leaves open clinical translation in oncology.
Mohammed et al. (2019) studied Doxorubicin-induced neurotoxicity. N-acetylcysteine (NAC) vs. Doxorubicin alone and saline control was evaluated on Neurotoxicity markers (body weight, TNF-α, MDA, total protein, GSH, GPx, and histopathology). N-acetylcysteine demonstrated a neuroprotective effect against doxorubicin-induced brain damage in rats by inhibiting inflammation and oxidative stress.
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