Key result
Caffeic acid phenethyl ester (CAPE) prevented doxorubicin-induced oxidant injury in rat brain, evidenced by lower malondialdehyde levels and higher catalase activity compared to doxorubicin alone.
Authors
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Hypothesis-generating for CAPE in doxorubicin neuroprotection; human studies needed before clinical consideration.
Fadıllıoğlu et al. (2003) studied doxorubicin-induced neuronal oxidative injury. caffeic acid phenethyl ester (CAPE) vs. saline was evaluated on activities of antioxidant enzymes and levels of malondialdehyde (MDA) and nitric oxide (NO). Caffeic acid phenethyl ester (CAPE) prevented doxorubicin-induced oxidant injury in rat brain, evidenced by lower malondialdehyde levels and higher catalase activity compared to doxorubicin alone.
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