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May 28, 2025BiomoleculesOpen Access

Caffeic Acid Phenethyl Ester Protects Against Doxorubicin-Induced Cardiotoxicity via Inhibiting the ROS-MLKL-Mediated Cross-Talk Between Oxidative Stress and Necroptosis

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Why the study?

Doxorubicin clinical use is limited by cardiotoxicity, and the mechanism underlying the protective effect of caffeic acid phenethyl ester against doxorubicin-induced cardiotoxicity remained to be explored.

Does Caffeic acid phenethyl ester (CAPE) protect against doxorubicin-induced cardiotoxicity in preclinical models?

Population

Mice with doxorubicin-induced cardiotoxicity and in vitro H9c2 and AC16 cells

Comparison

CAPE treatment vs controls in doxorubicin-induced cardiotoxicity models

Design

In vivo and in vitro experimental preclinical study

Authors

CJChenying JiangTZTinghuang ZhangJGJiawen Gu

Discussion

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Member takes

Overview

Hypothesis-generating for CAPE in DIC; leaves open clinical translation pending human trials.

Structured PICO

Does Caffeic acid phenethyl ester (CAPE) protect against doxorubicin-induced cardiotoxicity in preclinical models?

P
Population
In vivo doxorubicin-induced cardiotoxicity model in mice (intraperitoneal injection of 3 mg/kg DOX) and in vitro H9c2 and AC16 cells
I
Intervention
Caffeic acid phenethyl ester (CAPE) pre-administration
C
Comparator
Doxorubicin alone (implied)
O
Outcome
Cardiac function, myocardial tissue histopathology, myocardial injury markers, oxidative stress, and necroptosis pathway changessurrogate

CAPE protects against doxorubicin-induced cardiotoxicity by inhibiting ROS-MLKL-mediated cross-talk between oxidative stress and necroptosis in preclinical models.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/6a76298cf1e99ff85ab24074https://doi.org/10.3390/biom15060783
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of CAPE on biochemical, histopathological and cardiac parameters in doxorubicin induced cardiotoxicity2025 · 1 citations
  2. 2Protective effects of caffeic acid phenethyl ester on doxorubicin‐induced cardiotoxicity in rats2004 · 153 citations
  3. 3Cinnamic Acid Derivatives as Cardioprotective Agents against Oxidative and Structural Damage Induced by Doxorubicin2021 · 29 citations
  4. 4Effects of caffeic acid phenethyl ester against doxorubicin‐induced neuronal oxidant injury2003 · 29 citations
  5. 5Caffeic acid phenethyl ester potentiates gastric cancer cell sensitivity to doxorubicin and cisplatin by decreasing proteasome function2018 · 29 citations