Why the study?
The protective effect of Caffeic acid phenethyl ester (CAPE) against doxorubicin-induced cardiotoxicity was investigated due to the cardiotoxic effects of doxorubicin.
Does Caffeic acid phenethyl ester (CAPE) prevent doxorubicin-induced cardiotoxicity in Wistar Albino rats?
Comparison
CAPE+DOX vs DOX only, CAPE only, and control
Design
Randomized preclinical study
Key result
Caffeic acid phenethyl ester treatment ameliorated doxorubicin-induced histopathological changes in the myocardium of rats, but did not significantly alter oxidative stress, MMP-2 gene expression, Troponin I levels, or ECG parameters.
Authors
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Caffeic acid may protect against doxorubicin toxicity in animals; hypothesis-generating, requires human trials before any clinical consideration.
Does Caffeic acid phenethyl ester (CAPE) prevent doxorubicin-induced cardiotoxicity in Wistar Albino rats?
In a rat model, CAPE ameliorated doxorubicin-induced myocardial histopathological damage but did not improve biochemical or electrocardiographic markers of cardiotoxicity.
Olcay Murat Dişli (2025) studied Doxorubicin-induced cardiotoxicity (n=40). Caffeic acid phenethyl ester (CAPE) vs. Doxorubicin only and Control (saline + 2.5% ethanol) was evaluated on Histopathological changes, oxidative stress parameters, MMP-2 gene expression, Troponin I, and ECG changes. Caffeic acid phenethyl ester treatment ameliorated doxorubicin-induced histopathological changes in the myocardium of rats, but did not significantly alter oxidative stress, MMP-2 gene expression, Troponin I levels, or ECG parameters.
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