Key result
Periovulatory decline in neutrophils is linked to rising LDL cholesterol in healthy young women.
Why the study?
Experimental work showed that neutropenia selectively elevates LDL cholesterol in male but not female mice, suggesting estrogen may attenuate neutrophil-associated LDL regulation. Whether a comparable phase- and sex-dependent association between neutrophils and LDL is detectable in healthy humans had not been examined.
Does a periovulatory decline in circulating neutrophils coincide with a rise in circulating LDL-cholesterol in healthy young women?
Observational
Does a periovulatory decline in circulating neutrophils coincide with a rise in circulating LDL-cholesterol in healthy young women?
This study investigates whether a menstrual phase-dependent decline in circulating neutrophils coincides with a rise in LDL-cholesterol in healthy young women.
OBJECTIVE: Prior experimental work indicated that neutropenia selectively elevates circulating low-density lipoprotein (LDL) cholesterol in male but not female mice, suggesting that estrogen may attenuate a neutrophil-associated mechanism of LDL regulation. Whether a comparable phase- and sex-dependent association between neutrophils and LDL is detectable in healthy humans has not been examined.
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Sevım et al. (2026) conducted an observational in Healthy young women. Periovulatory phase / decline in circulating neutrophils vs. Other menstrual cycle phases within the same subject was evaluated on Circulating low-density lipoprotein (LDL) cholesterol levels. Periovulatory decline in circulating neutrophils coincided with a rise in low-density lipoprotein-cholesterol in healthy young women (quantitative results not provided in abstract).
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