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November 26, 2018Anti-Cancer Drugs

Caffeic acid phenethyl ester potentiates gastric cancer cell sensitivity to doxorubicin and cisplatin by decreasing proteasome function

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Why the study?

Caffeic acid phenethyl ester possesses antioxidant and anticancer effects, motivating investigation into its effectiveness on the cytotoxicity of doxorubicin and cisplatin in stomach and colon cancer cells.

Does CAPE enhance the sensitivity of gastric and colon cancer cells to doxorubicin and cisplatin?

Population

Parental and drug-resistant stomach (MKN45) and colon (LoVo) cancer cells

Comparison

Concomitant treatment with CAPE plus DXR or CDDP vs DXR or CDDP alone

Design

In vitro preclinical laboratory study

Authors

TMToshiyuki MatsunagaSTSaeka TsuchimuraNANozomi Azuma

Discussion

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Member takes

Overview

May support CAPE as chemotherapy sensitizer in gastric/colon cancers; hypothesis-generating from animal data only.

Structured PICO

Does CAPE enhance the sensitivity of gastric and colon cancer cells to doxorubicin and cisplatin?

P
Population
Parental and drug-resistant cells of stomach (MKN45) and colon (LoVo) cancers
I
Intervention
Caffeic acid phenethyl ester (CAPE) combined with doxorubicin (DXR) or cisplatin (CDDP)
C
Comparator
Doxorubicin (DXR) or cisplatin (CDDP) alone, or untreated cells
O
Outcome
Cytotoxicity and apoptotic effectssurrogate

CAPE enhances the sensitivity of gastric and colon cancer cells to doxorubicin and cisplatin by decreasing proteasome function, suggesting potential as an adjuvant in chemotherapy.

Cite This Study

Matsunaga et al. (2018) studied this question.

synapsesocial.com/papers/6a8e9bd1e3420198dacd6bdbhttps://doi.org/10.1097/cad.0000000000000715
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Caffeic acid phenethyl ester promotes oxaliplatin sensitization in colon cancer by inhibiting autophagy2024 · 9 citations
  2. 2Caffeic Acid Phenethyl Ester Protects Against Doxorubicin-Induced Cardiotoxicity via Inhibiting the ROS-MLKL-Mediated Cross-Talk Between Oxidative Stress and Necroptosis2025 · 4 citations
  3. 3Caffeic acid phenethyl ester attenuates changes in pancreatic tissue damage biomarkers induced by cisplatin2019 · 13 citations
  4. 4Effects of CAPE on biochemical, histopathological and cardiac parameters in doxorubicin induced cardiotoxicity2025 · 1 citations
  5. 5Caffeic Acid Phenethyl Ester (CAPE) Inhibits Hepatocellular Carcinoma Growth and Angiogenesis via Vascular Endothelial Growth Factor Suppression: A Preclinical Evidence2026