Why the study?
Doxorubicin's clinical usefulness is restricted by cardiotoxicity, prompting evaluation of the potential protective effects of the antioxidant vitamin E.
Does vitamin E prevent doxorubicin-induced cardiotoxicity in adult male albino rats?
Population
Forty 3-months adult male albino rats weighing 200-250 gm
Comparison
Vitamin E plus doxorubicin vs doxorubicin alone vs saline control vs untreated control
Design
Animal experimental study
Authors
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Vitamin E may mitigate doxorubicin cardiotoxicity in rats; hypothesis-generating and should not change practice pending human trials.
Does vitamin E prevent doxorubicin-induced cardiotoxicity in adult male albino rats?
Vitamin E supplementation ameliorates doxorubicin-induced cardiac histological damage and biochemical alterations in a rat model.
Abdel-Samia et al. (2019) studied this question.
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