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September 5, 2018Turkish Journal of BiochemistryOpen Access

Administration of hesperidin and/or vitamin E with doxorubicin reduced serum LDH, CK, MPO, MDA, and NO, and increased GSH, arylesterase, and paraoxonase compared to doxorubicin alone.

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Why the study?

Does hesperidin and vitamin E prevent doxorubicin-induced cardiomyopathy in a rat model?

Population

70 rats (model for doxorubicin-induced cardiomyopathy)

Comparison

Hesperidin and/or Vitamin E administered with… vs Doxorubicin alone (4 mg/kg, intraperitoneally)

Design

Preclinical

Authors

TDThoria DoniaSESamar EldalyEAEhab M. M. Ali

Discussion

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Overview

Hypothesis-generating for cardioprotection in doxorubicin therapy; clinical studies required before any practice change.

Structured PICO

Does hesperidin and vitamin E prevent doxorubicin-induced cardiomyopathy in a rat model?

P
Population
70 rats (model for doxorubicin-induced cardiomyopathy)
I
Intervention
Hesperidin (50 mg/kg, orally) and/or Vitamin E (100 mg/kg orally) administered with Doxorubicin
C
Comparator
Doxorubicin alone (4 mg/kg, intraperitoneally)
O
Outcome
Cardioprotective effect assessed by cardiac and serum biomarkers of oxidative stress, inflammation, apoptosis, and cardiac histopathologysurrogate

Hesperidin and vitamin E demonstrate cardioprotective effects against doxorubicin-induced cardiomyopathy in a rat model by reducing oxidative stress and inflammation.

Cite This Study

Donia et al. (2018) studied this question.

synapsesocial.com/papers/6a7ca64c041f7ddee0ba6176https://doi.org/10.1515/tjb-2018-0156
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of hesperidin as a cardioprotective strategy against doxorubicin-induced cardiotoxicity: The antioxidant, anti-inflammatory, antiapoptotic, and cytoprotective potentials2023 · 15 citations
  2. 2Cardio-protective Effect of Vitamin E on Doxorubicin-Induced Cardiotoxicity in Adult Male Albino Rats: A Histological and Biochemical Study2019 · 9 citations
  3. 3Protective effect of<i>Hypericum hircinum</i>on doxorubicin-induced cardiotoxicity in rats2012 · 21 citations
  4. 4Influence of DL α-lipoic acid and vitamin-E against doxorubicin-induced biochemical and histological changes in the cardiac tissue of rats2005 · 14 citations
  5. 5Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy2020 · 14 citations