Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2005Indian Journal of Pharmacology

Post-treatment with lipoic acid and vitamin E protected the myocardium from doxorubicin-induced toxicity, but only vitamin E was effective as a preventive therapy.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does lipoic acid and vitamin E prevent or cure doxorubicin-induced cardiotoxicity in Wistar albino rats?

Population

Wistar albino rats with doxorubicin-induced cardiotoxicity

Comparison

Lipoic acid and vitamin E administered as… vs Doxorubicin-treated group without antioxidant…

Design

Preclinical

Follow-up

30 days

Key result

Post-treatment with lipoic acid and vitamin E protected the myocardium from doxorubicin-induced toxicity, but only vitamin E was effective as a preventive therapy.

Authors

KPKK PillaiSASA AyazUBUma Bhandari

Discussion

Loading...

Member takes

Overview

Vitamin E may outperform lipoic acid for preventive and curative cardioprotection in rat models; leaves open clinical translation.

Structured PICO

Does lipoic acid and vitamin E prevent or cure doxorubicin-induced cardiotoxicity in Wistar albino rats?

P
Population
Wistar albino rats treated with doxorubicin to produce cardiotoxicity, monitored after 30 days.
I
Intervention
Lipoic acid and vitamin E administered as pretreatment and post-treatment
C
Comparator
Doxorubicin-treated group without antioxidant therapy
O
Outcome
Biochemical parameters (tissue GSH, MDA, LDH, CAT, SOD, GPx, GR, GST, and G6PD) and histopathological changes at 30 dayssurrogate

In a rat model, vitamin E provides both preventive and curative protection against doxorubicin-induced cardiotoxicity, whereas lipoic acid is effective only as a curative therapy.

Cite This Study

Pillai et al. (2005) studied Doxorubicin-induced cardiotoxicity. Lipoic acid and vitamin E vs. Doxorubicin-treated group was evaluated on Biochemical parameters (GSH, MDA, LDH, CAT, SOD, GPx, GR, GST, G6PD) and histopathological changes. Post-treatment with lipoic acid and vitamin E protected the myocardium from doxorubicin-induced toxicity, but only vitamin E was effective as a preventive therapy.

synapsesocial.com/papers/6ab3785f3550cfb2c045d46ehttps://doi.org/10.4103/0253-7613.16852
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardio-protective Effect of Vitamin E on Doxorubicin-Induced Cardiotoxicity in Adult Male Albino Rats: A Histological and Biochemical Study2019 · 9 citations
  2. 2Ameliorating oxidative stress and inflammation by Hesperidin and vitamin E in doxorubicin induced cardiomyopathy2018 · 17 citations
  3. 3Activity of d,l‐α‐Tocopherol (Vitamin E) against Cardiotoxicity Induced by Doxorubicin and Doxorubicin with Cyclophosphamide in Mice2005 · 48 citations
  4. 4Cardioprotective effect of ascorbic acid on doxorubicin-induced myocardial toxicity in rats2011 · 102 citations
  5. 5Allicin and L-carnitine as Preventive Agents Against Doxorubicin-induced Cardiac Damage in Rats2024 · 11 citations