July 30, 2013Acta Biochimica et Biophysica Sinica

-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Doxorubicin-induced cardiotoxicity. Intervention: alpha-Linolenic acid (ALA) vs. Doxorubicin alone, normal saline, and ALA alone. Primary outcome: Cardiotoxicity markers including heart weight, BNP, CK-MB, LDH, cTnI, and myocardial necrosis.

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Key result

Co-treatment with alpha-linolenic acid significantly attenuated doxorubicin-induced cardiotoxicity in rats by enhancing antioxidant defense and anti-apoptotic pathways.

Authors

XYXiaohua YuQujiang People's Hospital LCLi-Bao CuiHengyang Normal University ZZZizhen ZhangZhejiang Industry Polytechnic College

Discussion

Member takes

Implication

Should not yet change doxorubicin regimens; leaves open translation of rat cardioprotection to human trials.

Study Design

Type

RCT

Randomization

Randomly divided

PICO

Population

Rats treated with doxorubicin and/or alpha-linolenic acid for 17 days to assess cardioprotective effects.

Intervention / Comparator

alpha-Linolenic acid (ALA) vs Doxorubicin alone, normal saline, and ALA alone (500 µg/kg)

Primary Outcome

Cardiotoxicity markers including heart weight, BNP, CK-MB, LDH, cTnI, and myocardial necrosis

Cite This Study

Yu et al. (2013) conducted an RCT in Doxorubicin-induced cardiotoxicity. alpha-Linolenic acid (ALA) vs. Doxorubicin alone, normal saline, and ALA alone was evaluated on Cardiotoxicity markers including heart weight, BNP, CK-MB, LDH, cTnI, and myocardial necrosis. Co-treatment with alpha-linolenic acid significantly attenuated doxorubicin-induced cardiotoxicity in rats by enhancing antioxidant defense and anti-apoptotic pathways.

synapsesocial.com/papers/6a7aef08162060f9da891998 https://doi.org/10.1093/abbs/gmt082

Topics

Heart failure HFrEF treatment Bremelanotide

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-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis

Discussion

Member takes

Implication

Study Design

PICO

Cite This Study

Topics

-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis

Discussion

Member takes

Implication

Study Design

PICO

Cite This Study

Also Consider

Topics

Also Consider