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January 1, 2023Open Veterinary JournalOpen Access

The role of hesperidin as a cardioprotective strategy against doxorubicin-induced cardiotoxicity: The antioxidant, anti-inflammatory, antiapoptotic, and cytoprotective potentials

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Key result

Co-treatment with hesperidin protected cardiac tissues against doxorubicin-induced cardiotoxicity by ameliorating histological abnormalities and normalizing biochemical values in Wistar rats.

Why the study?

Doxorubicin use is restricted by cardiotoxicity linked to oxidative stress, and enhancing antioxidant capacity with agents such as hesperidin represents a promising cardioprotective approach.

Does hesperidin prevent doxorubicin-induced cardiotoxicity in Wistar rats?

Population

Wistar rats

Comparison

DOX plus HES vs DOX alone

Design

Animal experimental study

Follow-up

Five consecutive weeks

Authors

FAFawiziah Khalaf AlharbiZAZafer Saad AlshehriFAFaez Falah Alshehri

Discussion

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Member takes

Overview

Hypothesis-generating for hesperidin cardioprotection; leaves open translation to human doxorubicin regimens.

Structured PICO

Does hesperidin prevent doxorubicin-induced cardiotoxicity in Wistar rats?

P
Population
Wistar rats treated with doxorubicin to induce cardiotoxicity, with or without hesperidin co-treatment for five weeks.
I
Intervention
Hesperidin (100 mg/kg bw/day orally, 5 days a week for five consecutive weeks) co-administered with doxorubicin
C
Comparator
Doxorubicin alone (4 mg/kg bw once a week for five consecutive weeks, intraperitoneally)
O
Outcome
Cardiotoxicity assessed by histological, immunohistochemical, and biochemical parameterssurrogate

Hesperidin demonstrates significant cardioprotective effects against doxorubicin-induced cardiotoxicity in a rat model through anti-inflammatory, antioxidant, and antiapoptotic mechanisms.

Cite This Study

Alharbi et al. (2023) studied Doxorubicin-induced cardiotoxicity. Hesperidin vs. Doxorubicin alone was evaluated on Cardiotoxicity (histological, immunohistochemical, and biochemical assessments). Co-treatment with hesperidin protected cardiac tissues against doxorubicin-induced cardiotoxicity by ameliorating histological abnormalities and normalizing biochemical values in Wistar rats.

synapsesocial.com/papers/6a71acccb5c1fe5ca9dfe108https://doi.org/10.5455/ovj.2023.v13.i12.20
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ameliorating oxidative stress and inflammation by Hesperidin and vitamin E in doxorubicin induced cardiomyopathy2018 · 17 citations
  2. 2Hesperidin Reduces Hepatic Injury Induced by Doxorubicin in Rat Model Through Its Antioxidative and Anti‐Inflammatory Effects, Focusing on SIRT‐1/NRF‐2 Pathways2025
  3. 3Protective effect of<i>Hypericum hircinum</i>on doxorubicin-induced cardiotoxicity in rats2012 · 21 citations
  4. 4[Hesperetin alleviates doxorubicin-induced cardiotoxicity by regulating the AMPK/NLRP3 pathway].2025
  5. 5Role of diosmin in preventing doxorubicin-induced cardiac oxidative stress, inflammation, and hypertrophy: A mechanistic approach2024 · 1 citations