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October 2, 2025

Hesperetin alleviates doxorubicin-induced cardiotoxicity by regulating the AMPK/NLRP3 pathway.

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Authors

AYAili YanMLM. X. LuoJCJin-Rui Chang

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Overview

Laboratory analysis reveals that hesperetin significantly alleviates cardiotoxicity from doxorubicin, suggesting a protective anti-inflammatory effect through the AMPK/NLRP3 pathway.

Key Points

  • Hesperetin treatment sharply reduced doxorubicin-induced cardiotoxicity in H9c2 cells and mice.
  • Doxorubicin increased cell apoptosis and lactate dehydrogenase activity, while hesperetin reversed these effects.
  • The AMPK/NLRP3 pathway was significantly activated by hesperetin, indicating its role in reducing inflammation.
  • Inhibition of AMPK with compound C prevented the protective effects of hesperetin, highlighting its significance.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68de5d9383cbc991d0a1ffdahttps://doi.org/10.12122/j.issn.1673-4254.2025.09.05
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Also Consider

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  1. 1Hesperetin mitigates sorafenib-induced cardiotoxicity in mice through inhibition of the TLR4/NLRP3 signaling pathway2022 · 39 citations
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