Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025European Heart Journal Supplements

Cardioprotective effects of the flavonoid quercetin against doxorubicin-Induced cardiotoxicity in H9c2 cardiomyoblasts

View Full Paper
Ask AI
Bookmark
Share

Authors

NCN.W.S. ChongKKK Konteh

Discussion

Loading...

Member takes

Overview

In vitro analysis shows quercetin mitigates doxorubicin-induced cardiotoxicity in H9c2 cells, suggesting antioxidant potential.

Key Points

  • Doxorubicin significantly reduces H9c2 cell viability, highlighting its cardiotoxic effects in cancer treatment.
  • Pre-treatment with quercetin notably increased cell viability from 19% to 58%, indicating its protective role.
  • Oxidative stress appears to play a key role in doxorubicin-induced cell death, which quercetin effectively counters.
  • Ferroptosis blockade may contribute to quercetin's cardioprotective effects, revealing potential for novel treatments.

Cite This Study

Chong et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5e554b1d3bfb60df1ffhttps://doi.org/10.1093/eurheartjsupp/suaf083.235
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protective Effects of Quercetin, Curcumin and Resveratrol in an in Vitro Model of Doxorubicin-Induced Cardiotoxicity2025 · 1 citations
  2. 2Quercetin-induced cardioprotection against doxorubicin cytotoxicity2013 · 82 citations
  3. 3Mitigating Doxorubicin-Induced Cardiotoxicity through Quercetin Intervention: An Experimental Study in Rats2024 · 23 citations
  4. 4Myricetin Prevents Doxorubicin-Induced Oxidative Stress and Mitochondrial Apoptotic Pathway in H9C2 Cardiac Cells2025
  5. 5Possible protective effects of quercetin on doxorubicin-induced cardiotoxicity in rats2021 · 15 citations