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September 17, 2025Open Access

Myricetin Prevents Doxorubicin-Induced Oxidative Stress and Mitochondrial Apoptotic Pathway in H9C2 Cardiac Cells

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Authors

AAAzadeh AminzadehKerman University of Medical Sciences

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Overview

This experimental study illustrates that myricetin prevents oxidative stress and cardiotoxicity in H9C2 cells, suggesting potential therapeutic benefits.

Key Points

  • Myricetin increased cell viability in H9C2 cells exposed to doxorubicin, signaling protective effects against toxicity.
  • Treatment with doxorubicin significantly reduced total thiol molecules and total antioxidant capacity levels.
  • Myricetin pretreatment decreased both the Bax/Bcl-2 ratio and cleaved caspase-3 expression, indicative of diminished apoptotic activity.
  • Findings highlight myricetin as a viable therapeutic candidate for mitigating doxorubicin’s harmful effects on cardiac cells.

Cite This Study

Azadeh Aminzadeh (2025) studied this question.

synapsesocial.com/papers/68d4605131b076d99fa5fb19https://doi.org/10.21203/rs.3.rs-7226100/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myricetin Prevents Doxorubicin-Induced Oxidative Stress, Apoptotic Pathway, and Inflammation in H9C2 Cardiac Cells2026
  2. 2Myricitrin Protects against Doxorubicin‐Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERK/P53 Pathway2016 · 53 citations
  3. 3Cardioprotective potentials of myricetin on doxorubicin-induced cardiotoxicity based on biochemical and transcriptomic analysis2024 · 9 citations
  4. 4Protective effect of<i>Mutellina purpurea</i>polyphenolic compounds in doxorubicin-induced toxicity in H9c2 cardiomyocytes2014 · 11 citations
  5. 5In-silico and In-vivo Investigations Reveal Ameliorative Potential of Myricetin Against Doxorubicin-induced Myocardial Damage via Modulation of NF-κB Signaling Pathway2025