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October 7, 2025Current Protein and Peptide Science

In-silico and In-vivo Investigations Reveal Ameliorative Potential of Myricetin Against Doxorubicin-induced Myocardial Damage via Modulation of NF-κB Signaling Pathway

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Authors

PBPurvaj G. BaroteHPHarshal D. PawarMSM.I. Sayyed

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Overview

In-vivo analysis shows myricetin improves myocardial health in doxorubicin-treated rats, suggesting its protective role against cardiotoxicity.

Key Points

  • Myricetin significantly reduced doxorubicin-induced myocardial injury in rats, highlighting its protective role.
  • Treatment with myricetin decreased levels of cardiac injury markers SGPT, SGOT, CK-MB, and LDH after doxorubicin exposure.
  • Molecular docking confirmed strong binding of myricetin to nf-kb, implicating its role in inflammatory modulation.
  • Myricetin improved cardiac oxidative stress markers and reduced inflammatory cytokines, indicating comprehensive cardioprotection.

Cite This Study

Barote et al. (2025) studied this question.

synapsesocial.com/papers/68e585d0b1e78cc4e5f464dehttps://doi.org/10.2174/0113892037383576250909075917
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardioprotective potentials of myricetin on doxorubicin-induced cardiotoxicity based on biochemical and transcriptomic analysis2024 · 9 citations
  2. 2Myricitrin Protects against Doxorubicin‐Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERK/P53 Pathway2016 · 53 citations
  3. 3Myricetin Prevents Doxorubicin-Induced Oxidative Stress, Apoptotic Pathway, and Inflammation in H9C2 Cardiac Cells2026
  4. 4Myricetin Prevents Doxorubicin-Induced Oxidative Stress and Mitochondrial Apoptotic Pathway in H9C2 Cardiac Cells2025
  5. 5Myricetin protects against doxorubicin-induced acute kidney injury in rats by mitigating oxidative damage and apoptotic response2025 · 12 citations