Key result
Rutin, chlorogenic acid, Mutellina purpurea extract, and quercetin showed protective effects against doxorubicin-induced cytotoxicity in H9c2 cardiomyocytes, with rutin being the most promising.
Why the study?
Do Mutellina purpurea extract and other plant antioxidants protect against doxorubicin-induced toxicity in H9c2 cardiomyocytes?
Population
H9c2 cardiomyocytes (in vitro model of doxorubicin-induced toxicity)
Comparison
Mutellina purpurea methanolic extract fraction… vs Doxorubicin alone (1 µM)
Design
Preclinical
Authors
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Should not change doxorubicin cardioprotection practice; leaves open whether these in vitro effects translate in vivo.
Do Mutellina purpurea extract and other plant antioxidants protect against doxorubicin-induced toxicity in H9c2 cardiomyocytes?
Rutin and other plant antioxidants show potential in mitigating doxorubicin-induced oxidative stress and cytotoxicity in an in vitro cardiomyocyte model.
Mańdziuk et al. (2014) studied Doxorubicin-induced toxicity. Mutellina purpurea methanolic extract fraction, rutin, quercetin, and chlorogenic acid vs. Doxorubicin alone was evaluated on Oxidative stress, morphological changes, and cell viability. Rutin, chlorogenic acid, Mutellina purpurea extract, and quercetin showed protective effects against doxorubicin-induced cytotoxicity in H9c2 cardiomyocytes, with rutin being the most promising.
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