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September 18, 2025Acta Medica BulgaricaOpen Access

Protective Effects of Quercetin, Curcumin and Resveratrol in an in Vitro Model of Doxorubicin-Induced Cardiotoxicity

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Authors

BSBoris Petrov StoyanovDSDenitsa StefanovaRBRadostina Bogdanova

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Overview

This in vitro analysis evaluates how quercetin and curcumin enhance H9c2 cell viability, suggesting they mitigate doxorubicin's cardiotoxic effects.

Key Points

  • Quercetin and curcumin significantly increased H9c2 cell viability following doxorubicin treatment, indicating protective effects.
  • Cell viability assessment shows that at 0.25 μM doxorubicin, quercetin and curcumin markedly improve outcomes in H9c2 cells.
  • The study utilizes an in vitro model to examine the cardioprotective effects of antioxidants against doxorubicin-induced toxicity.
  • Findings highlight the potential of natural antioxidants quercetin and curcumin in counteracting drug-induced cardiac damage.

Cite This Study

Stoyanov et al. (2025) studied this question.

synapsesocial.com/papers/68d461c231b076d99fa60e03https://doi.org/10.2478/amb-2025-00061
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardioprotective effects of the flavonoid quercetin against doxorubicin-Induced cardiotoxicity in H9c2 cardiomyoblasts2025 · 1 citations
  2. 2Quercetin-induced cardioprotection against doxorubicin cytotoxicity2013 · 82 citations
  3. 3Resveratrol significantly improves cell survival in comparison to dexrazoxane and carvedilol in a h9c2 model of doxorubicin induced cardiotoxicity2021 · 60 citations
  4. 4Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes2016 · 55 citations
  5. 5Mitigating Doxorubicin-Induced Cardiotoxicity through Quercetin Intervention: An Experimental Study in Rats2024 · 23 citations