Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 31, 2024AntioxidantsOpen Access

Mitigating Doxorubicin-Induced Cardiotoxicity through Quercetin Intervention: An Experimental Study in Rats

View Full Paper
Ask AI
Bookmark
Share

Authors

PDPatricia Lorena DulfIuliu Hațieganu University of Medicine and PharmacyCCCamelia Alexandra CoadǎIuliu Hațieganu University of Medicine and PharmacyAFAdrian FloreaIuliu Hațieganu University of Medicine and Pharmacy

Discussion

Loading...

Member takes

Implication

Experimental study shows quercetin improves cardiac function in rats given doxorubicin, suggesting cardioprotection.

Key Points

  • Quercetin treatment improved cardiac function and reduced markers of injury, indicating potential cardioprotection.
  • Increased serum NT pro-BNP levels were normalized through quercetin intervention, showing its beneficial effect.
  • In vivo study utilized Wistar rats, with groups treated with varying doses of quercetin alongside doxorubicin administration for two weeks, assessing cardiac ultrasound performance and serum markers for injury during treatment period. Additional harmful markers like γH2AX and 8HOdG were analyzed, revealing oxidative damage presence caused by doxorubicin before quercetin application.

Cite This Study

Dulf et al. (2024) studied this question.

synapsesocial.com/papers/68e5a0adb6db64358753b5cchttps://doi.org/10.3390/antiox13091068
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of quercetin in patients with myocardial infarction. A multicenter, randomized, and open-label pilot study2023 · 17 citations
  2. 2Effects of Quercetin on Blood Pressure: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials2016 · 313 citations
  3. 3BATMAN-TCM 2.0: an enhanced integrative database for known and predicted interactions between traditional Chinese medicine ingredients and target proteins2023 · 207 citations
  4. 4DrugBank 6.0: the DrugBank Knowledgebase for 20242023 · 1,764 citations
  5. 5Nrf2: a dark horse in doxorubicin-induced cardiotoxicity2023 · 89 citations