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April 13, 2015International Journal of Molecular SciencesOpen Access

Quercetin Improves Postischemic Recovery of Heart Function in Doxorubicin-Treated Rats and Prevents Doxorubicin-Induced Matrix Metalloproteinase-2 Activation and Apoptosis Induction

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Why the study?

Does quercetin prevent doxorubicin-induced cardiotoxicity and improve postischemic recovery in rat hearts?

Population

Doxorubicin-treated rats

Comparison

Prolonged administration of Quercetin (QCT) vs Doxorubicin alone (implied)

Design

Preclinical

Authors

MBMonika BartekováSlovak Academy of SciencesPŠPetra ŠimončíkováSlovak Academy of SciencesMFMária FogarassyováSlovak Academy of Sciences

Discussion

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Implication

Quercetin may protect rat hearts from doxorubicin cardiotoxicity; hypothesis-generating and requires clinical trials before any practice change.

Structured PICO

Does quercetin prevent doxorubicin-induced cardiotoxicity and improve postischemic recovery in rat hearts?

P
Population
Doxorubicin-treated rats
I
Intervention
Prolonged administration of Quercetin (QCT)
C
Comparator
Doxorubicin alone (implied)
O
Outcome
Postischemic recovery of heart function, ultrastructure of myocardium, matrix metalloproteinases (MMPs), biometric parameters, and apoptosis inductionsurrogate

Quercetin prevents doxorubicin-induced cardiotoxicity and improves ischemic tolerance in rat hearts, potentially via Akt kinase activation and connexin-43 up-regulation.

Cite This Study

Barteková et al. (2015) studied this question.

synapsesocial.com/papers/6a755d48cc7f6f86c703330chttps://doi.org/10.3390/ijms16048168
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity2004 · 74 citations
  2. 2ISCHAEMIC POST‐CONDITIONING PROTECTS BOTH ADULT AND AGED SPRAGUE‐DAWLEY RAT HEART FROM ISCHAEMIA–REPERFUSION INJURY THROUGH THE PHOSPHATIDYLINOSITOL 3‐KINASE–AKT AND GLYCOGEN SYNTHASE KINASE‐3β PATHWAYS2009 · 37 citations