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September 5, 2025Journal of Biochemical and Molecular Toxicology

Hesperidin Reduces Hepatic Injury Induced by Doxorubicin in Rat Model Through Its Antioxidative and Anti‐Inflammatory Effects, Focusing on SIRT‐1/NRF‐2 Pathways

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Authors

AEAlzahraa A. Elhemiely SEShaimaa H. El‐Fayoumi MGMohamed H. A. Gadelmawla

Discussion

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Overview

Observational analysis shows that hesperidin significantly reduces hepatotoxicity in rats exposed to doxorubicin, suggesting its therapeutic potential through sirt-1 and nrf2 pathways.

Key Points

Hesperidin effectively reduces liver injury caused by doxorubicin exposure, particularly at the 100 mg/kg dose.
Key indicators of hepatic damage, including MDA and MPO levels, were improved with hesperidin treatment.
In vivo analyses demonstrated the importance of sirt-1/nrf2 pathways in hepatoprotective effects against doxorubicin-induced oxidative stress.
This research emphasizes the therapeutic role of hesperidin in managing doxorubicin-induced toxicity and supports further exploration of its clinical applications.

Cite This Study

Elhemiely et al. (2025) studied this question.

synapsesocial.com/papers/68bb421a2b87ece8dc958971 https://doi.org/10.1002/jbt.70465

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September 5, 2025Journal of Biochemical and Molecular Toxicology

Hesperidin Reduces Hepatic Injury Induced by Doxorubicin in Rat Model Through Its Antioxidative and Anti‐Inflammatory Effects, Focusing on SIRT‐1/NRF‐2 Pathways

View Full Paper

Ask AI

Bookmark

Authors

AEAlzahraa A. Elhemiely SEShaimaa H. El‐Fayoumi MGMohamed H. A. Gadelmawla

Discussion

Member takes

Overview

Observational analysis shows that hesperidin significantly reduces hepatotoxicity in rats exposed to doxorubicin, suggesting its therapeutic potential through sirt-1 and nrf2 pathways.

Key Points

Hesperidin effectively reduces liver injury caused by doxorubicin exposure, particularly at the 100 mg/kg dose.
Key indicators of hepatic damage, including MDA and MPO levels, were improved with hesperidin treatment.
In vivo analyses demonstrated the importance of sirt-1/nrf2 pathways in hepatoprotective effects against doxorubicin-induced oxidative stress.
This research emphasizes the therapeutic role of hesperidin in managing doxorubicin-induced toxicity and supports further exploration of its clinical applications.

Cite This Study

Elhemiely et al. (2025) studied this question.

synapsesocial.com/papers/68bb421a2b87ece8dc958971 https://doi.org/10.1002/jbt.70465

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