Key result
Naringenin attenuated doxorubicin-induced hepatotoxicity in Wistar rats by diminishing oxidative stress and inflammation.
Why the study?
Doxorubicin use is constrained by dose-dependent hepatotoxicity, and antioxidants may impact Dox-induced liver injury.
Does naringenin prevent doxorubicin-induced liver dysfunction in Wistar rats?
Population
Wistar rats
Comparison
Naringenin (50 and 100 mg/kg b.wt.) vs Dox-induced hepatotoxicity alone
Design
Animal study
Follow-up
20 days
Authors
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Hypothesis-generating for naringenin hepatoprotection; leaves open translation to human doxorubicin regimens.
Does naringenin prevent doxorubicin-induced liver dysfunction in Wistar rats?
Naringenin shows potential in mitigating doxorubicin-induced hepatotoxicity in rats by reducing oxidative stress and inflammation.
Wali et al. (2020) studied Doxorubicin-induced hepatotoxicity. Naringenin was evaluated on Liver damage assessed by MDA, antioxidant enzymes, ROS, and inflammatory mediators. Naringenin attenuated doxorubicin-induced hepatotoxicity in Wistar rats by diminishing oxidative stress and inflammation.