Key result
Naringenin attenuated doxorubicin-induced hepatotoxicity in Wistar rats by diminishing oxidative stress and inflammation.
Why the study?
Doxorubicin use is constrained by dose-dependent hepatotoxicity, and antioxidants may impact Dox-induced liver injury.
Does naringenin prevent doxorubicin-induced liver dysfunction in Wistar rats?
Does naringenin prevent doxorubicin-induced liver dysfunction in Wistar rats?
Naringenin shows potential in mitigating doxorubicin-induced hepatotoxicity in rats by reducing oxidative stress and inflammation.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for naringenin hepatoprotection; leaves open translation to human doxorubicin regimens.
Doxorubicin (Dox) is an operational and largely used anticancer drug, used to treat an array of malignancies. Nonetheless, its beneficial use is constrained due to its renal and hepatotoxicity dose dependently. Numerous research findings favor the use of antioxidants may impact Dox-induced liver injury/damage. In the current study, Wistar rats were given naringenin (50 and 100 mg/kg b.wt.) orally for 20 days as prophylactic dose, against the hepatotoxicity induced by single intraperitoneal injection of Dox (20 mg/kg b.wt.). Potency of naringenin against the liver damage caused by Dox was assessed by measuring malonyl aldehyde (MDA) as a by-product of lipid peroxidation, biochemical estimation of antioxidant enzyme system, reactive oxygen species (ROS) level, and inflammatory mediators. Naringenin-attenuated ROS production, ROS-induced lipid peroxidation, and replenished reduced antioxidant armory, namely, catalase (CAT), glutathione reductase (GR), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione (GSH). Naringenin similarly diminished expression of Cox-2 and levels of NF-κB and other inflammatory molecules induced by the Dox treatment. Histology added further evidence to the defensive effects of naringenin on Dox-induced liver damage. The outcomes of the current study reveal that oxidative stress and inflammation are meticulously linked with Dox-triggered damage, and naringenin illustrates the potential effect on Dox-induced hepatotoxicity probably through diminishing the oxidative stress and inflammation.
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Wali et al. (2020) studied Doxorubicin-induced hepatotoxicity. Naringenin was evaluated on Liver damage assessed by MDA, antioxidant enzymes, ROS, and inflammatory mediators. Naringenin attenuated doxorubicin-induced hepatotoxicity in Wistar rats by diminishing oxidative stress and inflammation.
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