November 8, 2018Archives of Physiology and Biochemistry

Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats

View Full Paper

Ask AI

Bookmark

Why the study?

Does naringenin prevent doxorubicin-induced nephrotoxicity, oxidative stress, and inflammation in Wistar rats?

Structured PICO

Does naringenin prevent doxorubicin-induced nephrotoxicity, oxidative stress, and inflammation in Wistar rats?

Population

Wistar rats with doxorubicin-induced nephrotoxicity (induced by Dox 10 mg/kg body weight administered intraperitoneally once)

Intervention

Naringenin 50 and 100 mg/kg body weight administered orally daily for 21 days

Comparator

Doxorubicin treatment alone (and healthy control)

Outcome

Kidney function markers (blood urea nitrogen, creatinine, lactate dehydrogenase, kidney injury molecule-1), oxidative stress markers (antioxidant enzymes, malondialdehyde, nitric oxide), and inflammatory markers (NF-κB, TNF-α, PGE-2)surrogate

Naringenin protects against doxorubicin-induced nephrotoxicity in a rat model by attenuating oxidative stress and inflammatory pathways.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for naringenin renoprotection in Dox models; human trials required before clinical consideration.

Cite This Study

Khan et al. (2018) studied this question.

synapsesocial.com/papers/6a7d0372ff1a536db837cafd https://doi.org/10.1080/13813455.2018.1529799

View Full Paper

Ask AI

Bookmark

Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats

Structured PICO

Discussion

Implication

Cite This Study

Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider